Chemoselective Palladium-Catalyzed Cyanation of Alkenyl Halides

A palladium-catalyzed cyanation of alkenyl halides using acetone cyanohydrin is described. A number of structurally diverse alkenylic nitrile containing compounds was prepared in one step under optimized conditions. The reaction proved to be efficient, chemoselective, easy to perform, and tolerant of a number of functional groups.

https://pubs.acs.org/doi/abs/10.1021/ol500618w

标签： cyanide