TPAP-Catalyzed Direct Oxidation of Primary Alcohols to Carboxylic Acids

We present a simple, mild, and highly effective method for the direct conversion of primary alcohols to carboxylic acids. TPAP serves as the catalyst, and NMO·H₂O plays a dual role, acting as the co-oxidant and as a reagent for aldehyde hydrate stabilization. This previously unknown stabilizing effect of geminal diols by N-oxides is the key for the efficiency of the overall transformation.

https://pubs.acs.org/doi/abs/10.1021/ol2014335

标签： TPAP